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four dimensions (MELON-4D). The model uses a physics-based and data-informed free-energy function to describe the dynamic evolution of chromosomal territories (CTs), com-partments, and nuclear lamina. The physics-based part of the free-energy function is motivated by experimental features of the eukaryotic genome learned from Hi-C and imaging

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In this study, the authors introduce MELON-4D, a computational tool for modeling chromatin organization in four dimensions. Initially applied to the Drosophila nucleus, its versatility allows it to reveal the underlying forces shaping nuclear architecture and dynamics across eukaryotes.

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Four-Dimensional Mesoscale Liquid Model of Nucleus Resolves Chromatin ...

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